Ucp3

Symbol: Ucp3
Name: uncoupling protein 3 (mitochondrial, proton carrier)
Entrez gene ID: 22229
Ensembl gene ID: ENSMUSG00000032942
Species: Mouse (Taxid: 10090)

Functional description:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity). [UniProt]

Observation:

Metabolic intensity (daily food energy/body mass) correlates with longevity in MF1 mice. The animals with the highest quartile of metabolic intensities have a mean lifespan of 36% longer than animals with the lowest quartile of metabolic intensities. The highest metabolism of long-lived animals can be attributed to increased uncoupling Ucp3 [15153176].

Skeletal muscle mitochondria isolated from high metabolism mice are more uncoupled that those from low metabolism mice [15153176].



Assays: Organismal Lifespan

Classification:
  • Aging Associated
  • Longevity-Associated


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • UCP3 (9606)
  • UCP3 (9598)
  • UCP3 (9615)
  • UCP3 (9913)
  • Ucp3 (10090)
  • Ucp3 (10116)
  • UCP3 (9031)
  • ucp1 (7955)
  • ATUCP2 (3702)

  • Inparanoids
  • ENSRNOP00000024005 (10116)
  • ENSMUSP00000032958 (10090)
  • ENSMUSP00000032958 (10090)



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