DhHP-6

Symbol: DhHP-6
Name: Deterohemin-AlaHisThrValGluLys

Functional description:
Synthetic peptide

Observation:

Deuterohemin containing peptide deterohemin-AlaHisThrValGluLys (DhHP-6) significantly increases mean lifespan (P < 0.05), but not maximum lifespan. DhHP-6 also improves survival rate in acute heat-stress (35 degree Celsius) and rescues sensitivity to paraquat in acute oxidative stress. DhHP-6 treatment up-regulates SOD-3 and also regulates stress resistance genes such as hsp-16.1, hsp16.49 and sir-2.1 daf-16 and sir-2.1 genes are essential for the beneficial effect of DhHP-6 [20528576].



Interventions:
  • DhHP-6 treatment

  • Assays: Organismal Lifespan

    Classification:
  • Gero-Suppressant




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