SHE-3

Symbol: SHE-3
Name: Eleutherococcus senticosus


Observation:

Treatment of nematodes with the plant adaptogen Eleutherococcus senticosus (SHE-3; alias Acantopanax senticosus) increase stress resistance and mean lifespan in a dose-dependent manner. 250 microgram/ml SHE-3 signinifanclty increases lifespan between 10 and 20% 9 (P < 0.001), increase maximum lifepsan with 2-3 days and pospones the moment when the first individuals die. With higher concentrations, the effect is weakerm wheras at the highest concentrations (2500 microgram/mL) a lifespan shortenening effect of 15-25% (P < 0.001) occurs. Treatment with SHE-3 induces translocation of DAF-16 and activation of HSP-16 [18536978].



Interventions:
  • Eleutherococcus senticosus treatment +10 to +20%

  • Assays: Organismal Lifespan

    Classification:
  • Gero-Suppressant




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