Symbol: Mt2 Name: DNA methyltransferase 2 Alias: dDnmt2; Dnmt2 Entrez gene ID: 34632 Ensembl gene ID: FBgn0028707 Species: Fly (Taxid: 7227) Functional description: Methyltransferase 2; Methyltransferase 2 [Source:FlyBase gene name;Acc:FBgn0028707] [Ensembl]; The gene Methyltransferase 2 is referred to in FlyBase by the symbol Dmel\Mt2 (CG10692, FBgn0028707). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: tRNA methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity. There is experimental evidence that it is involved in the biological process: gene silencing; determination of adult lifespan; tRNA methylation; response to oxidative stress; DNA hypermethylation; telomere maintenance; DNA methylation involved in embryo development; response to heat; DNA methylation. 14 alleles are reported. The phenotype of these alleles is annotated with: eye disc posterior to the morphogenetic furrow. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: C-5 cytosine methyltransferase; DNA methylase, C-5 cytosine-specific, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [FlyBase] Observation: Overexpression of Dnmt2 extends mean and maximum lifespan [15533947]. Interventions: Assays: Organismal Lifespan Mean: +58 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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