Mt2

Symbol: Mt2
Name: DNA methyltransferase 2
Alias: dDnmt2; Dnmt2
Entrez gene ID: 34632
Ensembl gene ID: FBgn0028707
Species: Fly (Taxid: 7227)

Functional description:
Methyltransferase 2; Methyltransferase 2 [Source:FlyBase gene name;Acc:FBgn0028707] [Ensembl]; The gene Methyltransferase 2 is referred to in FlyBase by the symbol Dmel\Mt2 (CG10692, FBgn0028707). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: tRNA methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity. There is experimental evidence that it is involved in the biological process: gene silencing; determination of adult lifespan; tRNA methylation; response to oxidative stress; DNA hypermethylation; telomere maintenance; DNA methylation involved in embryo development; response to heat; DNA methylation. 14 alleles are reported. The phenotype of these alleles is annotated with: eye disc posterior to the morphogenetic furrow. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: C-5 cytosine methyltransferase; DNA methylase, C-5 cytosine-specific, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [FlyBase]

Observation:

Overexpression of Dnmt2 extends mean and maximum lifespan [15533947].



Interventions:
  • Mt2 overexpression

  • Assays: Organismal Lifespan
    Mean: +58

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • References:
  • 15533947: DNA methyltransferase gene dDnmt2 and longevity of Drosophila.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • TRDMT1 (9606)
  • TRDMT1 (9598)
  • TRDMT1 (9615)
  • TRDMT1 (9913)
  • Trdmt1 (10090)
  • Trdmt1 (10116)
  • TRDMT1 (9031)
  • trdmt1 (7955)
  • Mt2 (7227)
  • AgaP_AGAP004101 (7165)
  • AgaP_AGAP012836 (7165)
  • pmt1 (4896)
  • DNMT2 (3702)
  • Os01g0612000 (4530)

  • Inparanoids
  • ENSMUSP00000028055 (10090)
  • ENSRNOP00000038279 (10116)
  • ENSMMUP00000004254 (9544)
  • ENSP00000346652 (9606)
  • SPBC19C2.02 (4896)



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