|
Symbol: sip-1 Name: Stress Induced Protein 1 Entrez gene ID: 176471 Ensembl gene ID: F43D9.4 Species: Worm (Taxid: 6239) Functional description: Protein SIP-1; Stress-induced protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q20363] [Ensembl]; sip-1 encodes a member of the small heat shock family of proteins; loss of sip-1 function via antisense or large-scale RNAi experiments results in embryonic lethality and in a small but reproducible reduction in lifespan in otherwise long-lived animals, respectively, suggesting that sip-1 plays a role in embryonic development as well as regulation of adult lifespan; in addition, expression of sip-1 in E. coli is able to confer thermotolerance on the bacterium; sip-1 mRNA is detected in oocytes and developing embryos, with SIP-1 protein abundant and widely expressed in embryos that have not yet begun morphogenesis; sip-1 expression is regulated by the insulin/IGF-1 signaling (IIS) pathway. [WormBase] Observation: RNAi of sip-1 has no effect on wild-type adult lifespan, but slightly shortens the long lifespan of age-1(hx546) mutant animals [14668486]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit