SIM1

Symbol: SIM1
Name: Start Independent of Mitosis 1
Entrez gene ID: 854683
Ensembl gene ID: YIL123W
Species: Yeast (Taxid: 4932)

Functional description:
Sim1p; Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated [Source:SGD;Acc:S000001385] [Ensembl]

Observation:

Disruption of SIM1 shortens mean (87.5%), but not maximum, lifespan without causing any other gross changes in cell cycle parameter or growth characteristics [8810036].

Cells bearing deletions in CLB1-4 are unable to undergo mitosis and normally arrest in G2. SIM1 disruption in clb1-4 mutant backgrounds will allow a second round of DNA synthesis without mitosis [8574583]. sim1delta;uth1delta double mutants exhibit various defects, including binucleated cells, benomyl sensitivity, heat shock sensitivity, inability to store glycogen, sensitivity to starvation and failure of spores to germinate [10612745].



Interventions:
  • SIM1 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • psu1 (4896)
  • SIM1 (4932)
  • SUN4 (4932)
  • KLLA0F04433g (28985)
  • AGOS_AER372C (33169)



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