Symbol: NR3C1 Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Alias: GRL Entrez gene ID: 2908 Ensembl gene ID: ENSG00000113580 Species: Human (Taxid: 9606) Functional description: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity). [UniProt] Observation: The ER22/23EK variant of NR3C1 is correlated with longevity as well as relative gluccoritcoid resistance, greater insulin sensitivity, and lower total and low-density lipoprotein cholesterol levels in males [15276593].NR3C1 was found to be associated with longevity [22279548]. Assays: Organismal Lifespan Longevity Associated Variants: Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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