MTTP

Symbol: MTTP
Name: microsomal triglyceride transfer protein
Alias: MTP; ABL
Entrez gene ID: 4547
Ensembl gene ID: ENSG00000138823
Species: Human (Taxid: 9606)

Functional description:
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]; rate limiting step in lipoprotein synthesis; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. [UniProt]

Observation:

In a genome-wide scan for loci associated with exceptional longevity in 308 excpetinoal long-lived individuals (representing 17 sibships) a locus on chromosome 4 which maps to MTTP appears to be associated with long-lifespan in this group of subjects [11526246]. Siblings of centenarians are four times more likely to live into their 90s than control siblings [10326548]. Among a U.S.-based group of lon-lived individuals, there is a statistically significant under-representation of a risk allele of MTTP. These result was not replicated in a French-based longevity study, but this discrepancy could be due to a lack of statistically significance [11778046]. Howerver, another study failed to find a significant correlation between MTTP haplotype and longevity in1589 German nonagenarians, centenarians, and appropriately matched controls [15911777]. Neither the chromosomal loci nor MTTP were found to be associated with longevity in nonagenarian individuals in the Leiden Longevity study and Leiden 85-Plus Study [16611701]. Despite the lack of replication, humans homozysous for two on-functioning alleles of MTTP suffer from abetalipoproteinemia and lack of ApoB particles in serum. Also drugs that inhibit MTTP improve lipoprotein profiles.MTTP was found to be associated with longevity [16015282]. MTTP was found to be associated with longevity [17339647]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was not found to be associated with longevity [15911777]. MTTP was found to be associated with longevity [22496539].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • 11 different snps tested, not all given. 1.0 [17339647]
  • rs2866164 0.05 [22496539]
  • rs2866164 1.0 [16015282]
  • rs2866164 0.34 [15911777]
  • rs61733139 None [15911777]
  • rs1800591 0.032 [16611701]
  • rs1800591 0.64 [16611701]
  • rs61733139 0.32 [16611701]
  • rs1800591-rs61733139 0.61 [16611701]
  • rs1800591-rs61733139 0.46 [16611701]
  • rs61733139 0.43 [16611701]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • References:
  • 11778046: Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.
  • 11526246: A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.
  • 10326548: Siblings of centenarians live longer.
  • 16611701: Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.
  • 15911777: No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MTTP (9606)
  • MTTP (9598)
  • MTTP (9615)
  • MTTP (9913)
  • Mttp (10090)
  • Mttp (10116)
  • MTTP (9031)
  • mtp (7955)
  • LOC100332220 (7955)
  • Mtp (7227)
  • AgaP_AGAP010234 (7165)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit