Symbol: INS
Name: insulin
Entrez gene ID: 3630
Ensembl gene ID: ENSG00000254647
Species: Human
(Taxid: 9606)
Functional description:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. [UniProt]
Observation:
Expression of human insulin under an inducible heat shock promoter increases nematode lifespan by 25% and is also able to enhance the lifespan of daf-2 mutants [11274053]. INS was found to be associated with longevity [22406557; 19367319; 17989723; 19489743].
Interventions:
INS overexpression
+25%
Assays:
Organismal Lifespan
Longevity Associated Variants:
many SNPs 0.05 [19367319]
2 SNPs, not specified None [19489743]
rs3842755 0.0001 [22406557]
rs3842755 0.0001 [22406557]
Classification:
Aging-Suppressor
Positive Aging-Suppressor
Longevity-Associated
No Age Effect
Type:
Gene
Protein coding
References:
11274053: Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
19367319: Human longevity and 11p15.5: a study in 1321 centenarians.
22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
19489743: Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.
17989723: A novel sampling design to explore gene-longevity associations: the ECHA study.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
INS
(9606)
INS
(9598)
INS
(9615)
INS
(9913)
Ins2
(10090)
Ins2
(10116)
INS
(9031)
LOC100334156
(7955)
ins
(7955)
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