INS

Symbol: INS
Name: insulin
Entrez gene ID: 3630
Ensembl gene ID: ENSG00000254647
Species: Human (Taxid: 9606)

Functional description:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. [UniProt]

Observation:

Expression of human insulin under an inducible heat shock promoter increases nematode lifespan by 25% and is also able to enhance the lifespan of daf-2 mutants [11274053]. INS was found to be associated with longevity [22406557; 19367319; 17989723; 19489743].



Interventions:
  • INS overexpression +25%

  • Assays: Organismal Lifespan

    Longevity Associated Variants:
  • many SNPs 0.05 [19367319]
  • 2 SNPs, not specified None [19489743]
  • rs3842755 0.0001 [22406557]
  • rs3842755 0.0001 [22406557]

  • Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 11274053: Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
  • 19367319: Human longevity and 11p15.5: a study in 1321 centenarians.
  • 22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
  • 19489743: Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.
  • 17989723: A novel sampling design to explore gene-longevity associations: the ECHA study.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • INS (9606)
  • INS (9598)
  • INS (9615)
  • INS (9913)
  • Ins2 (10090)
  • Ins2 (10116)
  • INS (9031)
  • LOC100334156 (7955)
  • ins (7955)



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