SOD1

Symbol: SOD1
Name: superoxide dismutase 1, soluble
Entrez gene ID: 6647
Ensembl gene ID: ENSG00000142168
Species: Human (Taxid: 9606)

Functional description:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. [UniProt]

Observation:

Ubiquitous overexpression of SOD1 does not extend lifespan in mice. Homozyous transgenic mice with two- to five-fold overexpression of SOD1 in various tissues exhibit a light reduction in lifespan. Hemizygous transgenic mice, with 1.5- to 3-fold overexpression of SOD1 display no difference in lifespan compared with nontransgenic litermate controls [10719757]. Transgenic mice with a mutant SOD1 transgene develop neuronal cytoskeletal lesions resembling the human amytrophic lateral sclerosis (ALS) phenotype [8610185]. Transgenic mice overexpressing SOD1 (and having 3.1-fold higher cellular Cu,Zn SOD activity in the brain) have reduced infarct size following experimental cerebral ischemia [1763030].SOD1 was not found to be associated with longevity [24163049].



Interventions:
  • Ubiquitinous SOD1 overexpression

  • Assays: Organismal Lifespan

    Longevity Associated Variants:
  • rs4998557 0.52 [24163049]
  • rs2070424 0.77 [24163049]
  • rs1041740 0.998 [24163049]

  • Classification:
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SOD1 (9606)
  • SOD1 (9598)
  • SOD1 (9615)
  • SOD1 (9913)
  • SOD1 (9913)
  • Sod1 (10090)
  • Gm8566 (10090)
  • Sod1 (10116)
  • SOD1 (9031)
  • sod1 (7955)
  • Sod (7227)
  • SOD3 (7165)
  • sod-5 (6239)
  • sod-1 (6239)
  • sod1 (4896)
  • SOD1 (4932)
  • KLLA0E05567g (28985)
  • AGOS_AGL321W (33169)
  • GeneID:2682824 (148305)
  • NCU02133 (5141)
  • CSD1 (3702)
  • Os03g0351500 (4530)
  • Os07g0665200 (4530)

  • Inparanoids
  • ENSP00000270142 (9606)
  • ENSMUSP00000023707 (10090)
  • ENSRNOP00000058241 (10116)
  • ENSMMUP00000002283 (9544)
  • YJR104C (4932)
  • SPAC821.10c (4896)
  • ENSP00000270142 (9606)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit