Denigma

dkf-2

Symbol: dkf-2
Name: D Kinase Family
Entrez gene ID: 180121
Ensembl gene ID: T25E12.4
Species: Worm (Taxid: 6239)

Functional description:
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor. [UniProt]

Observation:

Adult median and maximal lifespan increases by 40% and 20%, respectively, in animals lacking dkf-2. dkf-2 deficiency also ameliorated heat stress.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • PRKD3 (9606)
  • PRKD3 (9598)
  • PRKD3 (9615)
  • PRKD3 (9913)
  • Prkd3 (10090)
  • Prkd3 (10116)
  • PRKD3 (9031)
  • prkd3 (7955)
  • PKD (7227)
  • AgaP_AGAP000070 (7165)
  • dkf-2 (6239)



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