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Symbol: Pi3K92E Name: Phosphatidylinositol-3-kinase Entrez gene ID: 42446 Ensembl gene ID: FBgn0015279 Species: Fly (Taxid: 7227) Functional description: CG4141 gene product from transcript CG4141-RB; Pi3K92E [Source:FlyBase gene name;Acc:FBgn0015279] [Ensembl]; The gene Pi3K92E is referred to in FlyBase by the symbol Dmel\Pi3K92E (CG4141, FBgn0015279). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: 1-phosphatidylinositol-4-phosphate 3-kinase activity; lipid kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity. There is experimental evidence for 23 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; instar larval development; regulation of developmental process; response to stimulus; entry into diapause; phospholipid metabolic process; larval feeding behavior; gland morphogenesis; response to stress; embryonic development via the syncytial blastoderm; catabolic process; metamorphosis; multicellular organism reproduction. 31 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system; organ system subdivision; adult segment; external compound sense organ; cell part; thoracic segment; cytoplasmic part; multicellular structure; peripheral nervous system; imaginal precursor. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Armadillo-type fold; C2 calcium/lipid-binding domain, CaLB; Phosphatidylinositol 3-/4-kinase, catalytic domain; Phosphatidylinositol 3-kinase, p85-binding; Phosphatidylinositol 3/4-kinase, conserved site; Phosphatidylinositol Kinase; Phosphoinositide 3-kinase, C2; Phosphoinositide 3-kinase, accessory (PIK) domain; Phosphoinositide 3-kinase, ras-binding; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. [FlyBase] Observation: Heterozyogous mutation in Pi3K92E fails to extend lifespan [11292874] and it is recessive lethal. Overexpression of a dominant-negative Pi3K92E (DP110) results in mutants that have impaired regeneration of the intestinal epithelium and are short lived with a reduction of the mean lifespan by 2.8% for males and 5.0% for females [20976250]. Interventions: Assays: Organismal Lifespan Mean: -2.8 to -5.0 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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