uba-1

Symbol: uba-1
Name: UBA (human ubiquitin) related
Entrez gene ID: 177855
Ensembl gene ID: C47E12.5
Species: Worm (Taxid: 6239)

Functional description:
Protein UBA-1; UBA (human ubiquitin) related family member (uba-1) [Source:RefSeq peptide;Acc:NP_001033404] [Ensembl]; uba-1 encodes the only known ubiquitin-activating enzyme in C. elegans and is orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and larval development and is required for proper formation of the male tail, sperm fertility, proper body size, meiotic progression in the embryo and germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome; experimental evidence demonstrates that uba-1 is invloved in protein ubiquitination; further, uba-1 shows synthetic lethal interactions with components of the anaphase-promoting complex (APC); a uba-1 transcriptional reporter fusion is expressed in the larval intestine. This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. [WormBase]

Observation:

Overexpression of uba-1 does not result in significant increase in median lifespan [22737090].



Interventions:
  • uba-1 overexpression

  • Assays: Organismal Lifespan

    Classification:
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • UBA1 (9606)
  • UBA1 (9598)
  • UBA1 (9615)
  • UBA1 (9913)
  • Uba1 (10090)
  • Uba1 (10116)
  • uba1 (7955)
  • Uba1 (7227)
  • AgaP_AGAP011872 (7165)
  • uba-1 (6239)
  • ptr3 (4896)
  • UBA1 (4932)
  • KLLA0B14278g (28985)
  • AGOS_AFR433C (33169)
  • GeneID:2679236 (148305)
  • NCU04370 (5141)
  • ATUBA1 (3702)
  • ATUBA2 (3702)
  • Os11g0106400 (4530)



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