Symbol: uba-1 Name: UBA (human ubiquitin) related Entrez gene ID: 177855 Ensembl gene ID: C47E12.5 Species: Worm (Taxid: 6239) Functional description: Protein UBA-1; UBA (human ubiquitin) related family member (uba-1) [Source:RefSeq peptide;Acc:NP_001033404] [Ensembl]; uba-1 encodes the only known ubiquitin-activating enzyme in C. elegans and is orthologous to Saccharomyces cerevisiae UBA1 and human UBE1; UBA-1 is essential for embryogenesis and larval development and is required for proper formation of the male tail, sperm fertility, proper body size, meiotic progression in the embryo and germline development; by homology, UBA-1 is predicted to function in an ATP-dependent reaction that activates ubiquitin prior to its conjugation to proteins that will subsequently be degraded by the 26S proteasome; experimental evidence demonstrates that uba-1 is invloved in protein ubiquitination; further, uba-1 shows synthetic lethal interactions with components of the anaphase-promoting complex (APC); a uba-1 transcriptional reporter fusion is expressed in the larval intestine. This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. [WormBase] Observation: Overexpression of uba-1 does not result in significant increase in median lifespan [22737090]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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