Denigma

ucp-4

Symbol: ucp-4
Name: UnCoupling Protein (mitochondrial substrate carrier) family member (ucp-4)
Entrez gene ID: 179315
Ensembl gene ID: K07B1.3
Species: Worm (Taxid: 6239)

Functional description:
Protein UCP-4; UnCoupling Protein (mitochondrial substrate carrier) family member (ucp-4) [Source:RefSeq peptide;Acc:NP_505414] [Ensembl]; ucp-4 encodes an uncoupling protein related to mammalian mitochondrial uncoupling protein 4 (UCP4) also known as solute carrier family 25, member 27 (SLC25A27); UCP-4 is predicted to function to uncouple ATP production from electron transport and, consistent with this, ucp-4 mutant animals contain elevated ATP levels; ucp-4 activity is also required for normal rates of survival in response to cold treatment; a ucp-4::gfp promoter fusion is expressed in head and body wall muscles and in the pharynx. [WormBase]

Observation:

Overexpression reduces mean lifespan by 5%, has no significant effect on median lifespan, and slighlty increases maximum lifespan by 12% [22737090].



Interventions:
  • ucp-4 overexpression -5% +12%

    • Assays: Organismal Lifespan

    Classification:
  • No Age Effect


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • SLC25A27 (9606)
  • SLC25A27 (9598)
  • SLC25A27 (9615)
  • SLC25A27 (9913)
  • Slc25a27 (10090)
  • Slc25a27 (10116)
  • slc25a27 (7955)
  • Ucp4A (7227)
  • AgaP_AGAP009603 (7165)
  • ucp-4 (6239)
  • AT1G14140 (3702)

    • Note: It has some effect on maximum lifespan though.

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