HPR1

Symbol: HPR1
Name: HyPerRecombination 1
Alias: TRF1
Entrez gene ID: 851716
Ensembl gene ID: YDR138W
Species: Yeast (Taxid: 4932)

Functional description:
Hpr1p; Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p [Source:SGD;Acc:S000002545] [Ensembl]

Observation:

Deletion of HPR1 decreases replicative lifespan [11756539]



Interventions:
  • HPR1 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HPR1 (4932)
  • KLLA0F11528g (28985)
  • AGOS_AGL181C (33169)



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