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Symbol: Gadd45 Name: growth arrest and DNA damage-inducible gene 45 Alias: D-GADD45 Entrez gene ID: 35646 Ensembl gene ID: FBgn0033153 Species: Fly (Taxid: 7227) Functional description: CG11086 gene product from transcript CG11086-RA; Gadd45 [Source:FlyBase gene name;Acc:FBgn0033153] [Ensembl]; The gene Gadd45 is referred to in FlyBase by the symbol Dmel\Gadd45 (CG11086, FBgn0033153). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: JNK cascade; regulation of oviposition. 5 alleles are reported. The phenotypes of these alleles are annotated with: chorion; follicle cell; egg chamber; dorsal appendage; nurse cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Growth arrest and DNA damage-inducible protein GADD45; Ribosomal protein L7Ae/L30e/S12e/Gadd45. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [FlyBase] Observation: Gadd45 overexpression in the nervous system leads to a significant increase of lifespan without a decrease in fecundity and locomotor activity. The lifespan extension effect is more pronounced in males than in females. Additional maximum lifespan is also extended. The maximum lifespan is increased by 50% and 59% for females and males, respectively. The median lifespan is extended by 46 and 77% for females and males, respectively [22661237]. Interventions: Assays: Organismal Lifespan Median: +46 to +77 Maximum: +50 to +59 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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