FOXO3

Symbol: FOXO3
Name: forkhead box O3
Entrez gene ID: 2309
Ensembl gene ID: ENSG00000118689
Species: Human (Taxid: 9606)

Functional description:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. [UniProt]

Observation:

FOXO3A gene polymorphism (rs3800231) may be important for achievement of longevity [22661237].FOXO3 was found to be associated with longevity [20884733]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [18765803]. FOXO3 was found to be associated with longevity [19196970]. FOXO3 was found to be associated with longevity [20849522]. FOXO3 was not found to be associated with longevity [20849522].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs2253310 7.9e-05 [19793722]
  • rs2802292 2.9e-05 [19793722]
  • rs4946936 1.8e-05 [19793722]
  • rs2764264 0.0002 [18765803]
  • rs13217795 0.0006 [18765803]
  • rs2802292 0.0001 [18765803]
  • rs9486902 0.0118 [20849522]
  • rs12206094 0.0076 [20849522]
  • rs2802292 0.0078 [20849522]
  • rs13220810 0.0223 [20849522]
  • rs2764264 0.05 [20849522]
  • rs7762395 0.05 [20849522]
  • rs13217795 0.05 [20849522]
  • rs9400239 0.05 [20849522]
  • rs9398172 0.05 [20849522]
  • rs3800231 0.0495 [20849522]
  • rs479744 0.05 [20849522]
  • FOXO3A, various 0.0002 [20884733]
  • rs6911407 0.006 [19196970]
  • rs768023 0.007 [19196970]
  • rs2802288 0.006 [19196970]
  • rs2274776 0.536 [19196970]
  • rs1571631 0.872 [19196970]
  • rs2883881 0.1 [19196970]
  • rs12200646 0.064 [19196970]
  • rs2802290 0.01 [19196970]
  • rs13220810 0.02 [19196970]
  • rs7762395 0.005 [19196970]
  • rs9400239 0.0007 [19196970]
  • rs3800231 0.0002 [19196970]
  • rs1268170 0.02 [19196970]
  • rs473268 0.044 [19196970]
  • rs519007 0.55 [19196970]
  • rs479744 0.001 [19196970]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • References:
  • 22661237: The second international conference "genetics of aging and longevity".


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • FOXO3 (9606)
  • FOXO3 (9913)
  • Foxo3 (10090)
  • Foxo3 (10116)
  • FOXO3 (9031)
  • foxo3b (7955)

  • Orthologs
  • daf-16 (6239)
  • foxo (7227)
  • daf-16 (6239)
  • foxo (7227)

  • Inparanoids
  • ENSP00000339527 (9606)
  • ENSMUSP00000101141 (10090)
  • ENSRNOP00000000327 (10116)
  • ENSMMUP00000032969 (9544)
  • SPBC4C3.12 (4896)
  • ENSP00000339527 (9606)



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