Symbol: FOXO3 Name: forkhead box O3 Entrez gene ID: 2309 Ensembl gene ID: ENSG00000118689 Species: Human (Taxid: 9606) Functional description: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. [UniProt] Observation: FOXO3A gene polymorphism (rs3800231) may be important for achievement of longevity [22661237].FOXO3 was found to be associated with longevity [20884733]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [18765803]. FOXO3 was found to be associated with longevity [19196970]. FOXO3 was found to be associated with longevity [20849522]. FOXO3 was not found to be associated with longevity [20849522]. Assays: Organismal Lifespan Longevity Associated Variants: Classification: References: Aging Relevance Analysis/Source: Homologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
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