ctbp-1

Symbol: ctbp-1
Name: CTBP (CtBP) transcriptional co-repressor homolog
Entrez gene ID: 180853
Ensembl gene ID: F49E10.5
Species: Worm (Taxid: 6239)

Functional description:
Protein CTBP-1; CTBP (CtBP) transcriptional co-repressor homolog family member (ctbp-1) [Source:RefSeq peptide;Acc:NP_508983] [Ensembl]; tag-45 encodes a D-isomer specific 2-hydroxyacid dehydrogenase. [WormBase]

Observation:

Genetic inactivation of ctbp-1 results in lifespan extension dependent on daf-16, but independent of sir-2.1. RNAi of lips-7(C09E8.2) suppresses lifespan extension by ctbp-1 inactivation [19164523].



Interventions:
  • ctbp-1 mutation

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ctbp2 (7955)
  • CtBP (7227)
  • AgaP_AGAP003893 (7165)
  • ctbp-1 (6239)



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