Symbol: ckr-1 Name: CholecystoKinin Receptor homolog 1 Entrez gene ID: 188774 Ensembl gene ID: T23B3.4 Species: Worm (Taxid: 6239) Functional description: Protein CKR-1; CholecystoKinin Receptor homolog family member (ckr-1) [Source:RefSeq peptide;Acc:NP_491918] [Ensembl]; T23B3.4 encodes a seven transmembrane receptor that is most closely related to the mammalian cholecystokinin receptors; loss of T23B3.4 activity via RNAi, either singly or in combination with another cholecystokinin receptor-encoding gene, Y39A3B.5, has no effect on fat metabolism, however large-scale RNAi screens have reported that T23B3.4(RNAi) results in embryonic lethality and reduced brood sizes; a T23B3.4::GFP reporter is expressed in a subset of nerve ring neurons. [WormBase] Observation: ckr-1 RNAi significantly reduces lifespan of eat-2 but not that of age-1 nor clk-1 mutants [19783783]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit