TP53

Symbol: TP53
Name: tumor protein p53
Alias: P53; LFS1; TRP53; FLJ92943
Entrez gene ID: 7157
Ensembl gene ID: ENSG00000141510
Species: Human (Taxid: 9606)

Functional description:
induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [UniProt]

Observation:

A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • Msp1 restriction fragment length polymorphism in intron 6 (G/A) 0.65 [15195682]
  • rs1042522 0.85 [15195682]
  • 16 bp duplication in intron 3 (WT=no duplicaiton) 0.59 [15195682]
  • rs1042522 0.006 [23125046]
  • rs1042522 0.006 [23125046]
  • - None [15621215]
  • TP53 1.0 [15621215]
  • rs1042522 0.005 [18256523]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • References:
  • 15732191: Variation in the human TP53 gene affects old age survival and cancer mortality.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • TP53 (9606)
  • TP53 (9598)
  • TP53 (9615)
  • TP53 (9913)
  • Trp53 (10090)
  • Tp53 (10116)
  • tp53 (7955)

  • Orthologs
  • p53 (7227)
  • p53 (7227)

  • Inparanoids
  • ENSMUSP00000104298 (10090)
  • ENSRNOP00000047840 (10116)
  • ENSMMUP00000035274 (9544)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit