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Symbol: des-2 Name: DEgeneration Suppressor Entrez gene ID: 179574 Ensembl gene ID: T26H10.1 Species: Worm (Taxid: 6239) Functional description: Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [UniProt] Observation: Mutations in both des(bs29) and des(bs30) increase lifespan by approximately 60%. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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