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Symbol: Pink1 Name: PTEN-induced putative kinase 1 Alias: Dmel_CG4523;BEST:GH23468;CG4523;Dmel\\CG4523;PINK;PINK1;dPINK1;dPink1;pink1 Entrez gene ID: 31607 Ensembl gene ID: FBgn0029891 Species: Fly (Taxid: 7227) Functional description: PTEN-induced putative kinase 1; PTEN-induced putative kinase 1 [Source:FlyBase gene name;Acc:FBgn0029891] [Ensembl]; The gene PTEN-induced putative kinase 1 is referred to in FlyBase by the symbol Dmel\Pink1 (CG4523, FBgn0029891). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of programmed cell death; mitochondrial fission; sperm mitochondrion organization; negative regulation of neuron apoptosis; compound eye development; response to oxidative stress; regulation of mitochondrion organization; mitochondrion organization. 21 alleles are reported. The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: organ system; organ system subdivision; cytoplasmic part; adult; organelle; external compound sense organ; adult segment; intracellular organelle; spermatozoon; elongation stage spermatid. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed in adult male stages. [FlyBase] Observation: Overexpression of Pink1 and overexpression of Pink1 with alpha-synclein results in an increase in lifespan which is accompanied by an increase in healthspan (as measured by mobility) when driven by a dopaminergic cells targeting TH-Gla4 transgene [22653599]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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