OSH7

Symbol: OSH7
Name: OxySterol binding protein Homolog 7
Entrez gene ID: 856389
Ensembl gene ID: YHR001W
Species: Yeast (Taxid: 4932)

Functional description:
Osh6p; Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000001711] [Ensembl]

Observation:

Overexpression of OSH7 extends mean replicative lifespan. PERG6-OSH7 does not extend the maximum lifespan significantly [Xia et al., unpublished].

Deletion of the CC domain of Osh7 (Perg6-OSH7-ORD) greatly shortens the lifespan. Deletion of the Osh7's CC domain decreases lifespan (Perg6-OSH7-ORD) shortens the lifespan [Tang et al., personal communication].

Osh7 interacts with the late endosome ATPase Vps4 by their C-terminal coiled-coil (CC) domain.



Interventions:
  • OSH7 overexpression
  • OSH7 mutation

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • OSBPL8 (9606)
  • OSBPL8 (9598)
  • OSBPL8 (9615)
  • Osbpl8 (10090)
  • Osbpl8 (10116)
  • OSBPL8 (9031)
  • CG5077 (7227)
  • AgaP_AGAP003484 (7165)
  • obr-3 (6239)
  • SPCC23B6.01c (4896)
  • OSH7 (4932)
  • KLLA0A02827g (28985)
  • AGOS_AEL287C (33169)



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