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Symbol: Prkar2b Name: protein kinase, cAMP dependent regulatory, type II beta Alias: Pkarb2;AI451071;AW061005;RII(beta) Entrez gene ID: 19088 Ensembl gene ID: ENSMUSG00000002997 Species: Mouse (Taxid: 10090) Functional description: regulatory subunit expressed in brain and adipose tissue; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. [UniProt] Observation: Loss of function of Prkar2b results in mice that are lean and insulin sensitive. Both median and maximum lifespan is increased by 14%. Median lifespan is increasesd (from 884 to 1005) and 80% lifespan increased from 941 to 1073 days. There is no difference either in median or 80% lifespan in female genotypes [19536287]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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