VPS27

Symbol: VPS27
Alias: Vacuolar Protein Sorting 27
Entrez gene ID: 855739
Ensembl gene ID: YNR006W
Species: Yeast (Taxid: 4932)

Functional description:
Vps27p; Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) [Source:SGD;Acc:S000005289] [Ensembl]

Observation:

Under starvation conditions VPS27 deletion mutants have a dramatically reduced lifespan [20953148].



Interventions:
  • VPS27 deletion

  • Assays: Chronological Lifespan

    Classification:
  • Aging Associated


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HGS (9606)
  • HGS (9598)
  • HGS (9615)
  • HGS (9913)
  • Hgs (10090)
  • Hgs (10116)
  • HGS (9031)
  • LOC100331756 (7955)
  • Hrs (7227)
  • AgaP_AGAP008887 (7165)
  • hgrs-1 (6239)
  • sst4 (4896)
  • VPS27 (4932)
  • KLLA0F06446g (28985)
  • AGOS_AFL176C (33169)
  • GeneID:2675537 (148305)
  • NCU04015 (5141)



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