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Symbol: daf-9 Name: abnormal DAuer Formation Entrez gene ID: 180889 Ensembl gene ID: T13C5.1 Species: Worm (Taxid: 6239) Functional description: Protein DAF-9; abnormal DAuer Formation family member (daf-9) [Source:RefSeq peptide;Acc:NP_741807] [Ensembl]; daf-9 encodes a cytochrome P450 of the CYP2 subfamily that by homology is predicted to function as a steroidogenic or fatty acid hydroxylase; DAF-9 likely functions cell nonautonomously in hypodermal and neuronal cells to produce, for the DAF-12 nuclear receptor, a lipophilic hormone whose presence is necessary for bypassing entry into the alternative L3/dauer larval stage and promoting reproductive development; in regulating dauer formation, daf-9 acts downstream of the DAF-2/insulin/IGF receptor and the DAF-7/TGFbeta ligand, suggesting that at least two of the signaling pathways that control dauer formation converge, in part, upon daf-9; in addition, daf-9 activity is required for gonadal cell migration; a DAF-9::GFP fusion is expressed in the XXXL/R head cells at all developmental stages, in hypodermal cells from the L2 to L4 larval stages, and in the spermatheca of adult hermaphrodites. [WormBase] Observation: Mutations in daf-9 increase lifespan up to 52% [11740945]. Mutation of daf-9 extends mean and maximum lifespan at 15 degree Celsius by 15-75% and 28-96%, respectively [11782415]. Lifespan extension conferred by mutation of daf-9 is suppressed by mutation of daf-12, but not by mutation of daf-16. daf-3 mutation results in a wild-type lfiespan, but greatly extends the long-lived daf-9 mutant lifespan. Genetic evidence suggests that daf-9 is positioned downstream of SMAD and forkhead transcription factors [11782415]. daf-9 mutants are dauer-constitutive [3350212], exhibit gonadal cell migration defect [11782415], and a post-dauer molting defect. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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