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Symbol: raga-1 Name: RAs-related GTP-binding protein A Entrez gene ID: 174726 Ensembl gene ID: T24F1.1 Species: Worm (Taxid: 6239) Functional description: Protein RAGA-1; RAs-related GTP-binding protein A family member (raga-1) [Source:RefSeq peptide;Acc:NP_496415] [Ensembl]; raga-1 encodes the C. elegans ortholog of the ras-related GTPase RagA; in C. elegans RAGA-1 functions as a modifier of behavioral aging and adult lifespan (particularly under high food concentration); raga-1 mutations also affect body size and reproduction; genetic analyses suggest that raga-1 functions in the let-363/Tor pathway to regulate behavioral aging and lifespan and also interacts with the daf-2/daf-16 insulin signaling pathway and skn-1; raga-1 reporter fusions are widely expressed in larvae, with more restricted expression (gut, head and tail neurons, somatic gonad, hypodermis) seen in adults. [WormBase] Observation: raga-1 RNAi only during adulthood increases mean, median, 75th %ile and maximum lifespan by 9-42, 26-28, 16-52 and 35%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Lifespan of the skn-1;daf-16 mutant was unaffected by raga-1 RNAi. Knockdown of raga-1 dramatically increases stress tolerance in an skn-1 but not daf-16-dependent manner [22560223]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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