VPS21

Symbol: VPS21
Name: Vacuolar Protein Sorting 21
Alias: VPS12; VPT12; YPT21; YPT51
Entrez gene ID: 854256
Ensembl gene ID: YOR089C
Species: Yeast (Taxid: 4932)

Functional description:
Vps21p; Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog [Source:SGD;Acc:S000005615] [Ensembl]

Observation:

Lack of VPS21 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825].



Interventions:
  • VPS21 deletion

  • Assays: Chronological Lifespan

    Classification:
  • DR-Essential


  • References:
  • 20657825: Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RAB5A (9606)
  • RAB5A (9598)
  • RAB5A (9615)
  • RAB5A (9913)
  • Rab5a (10090)
  • Rab5a (10116)
  • RAB5A (9031)
  • rab5aa (7955)
  • rab5ab (7955)
  • Rab5 (7227)
  • AgaP_AGAP007901 (7165)
  • rab-5 (6239)
  • VPS21 (4932)
  • KLLA0C13728g (28985)
  • AGOS_ACL084C (33169)
  • GeneID:2684396 (148305)
  • NCU06410 (5141)
  • RHA1 (3702)
  • ARA7 (3702)
  • Os12g0631100 (4530)
  • Os03g0666500 (4530)
  • Rab5c (5833)



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