asb-2

Symbol: asb-2
Name: ATP Synthase B homolog 2
Entrez gene ID: 180718
Ensembl gene ID: F02E8.1
Species: Worm (Taxid: 6239)

Functional description:
Mitochondrial F1F0-ATP synthase, subunit b/ATP4; Protein ASB-2; ATP Synthase B homolog family member (asb-2) [Source:RefSeq peptide;Acc:NP_508770] [Ensembl]; asb-2 encodes the B subunit of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V) that is closely similar to its paralog ASB-1; RNAi experiments indicate that asb-2 activity is required for larval development as well as for normal body morphology, lifespan, and growth rate. [WormBase]

Observation:

RNA interference of abs-2 leads to lifespan extension [16103914].



Interventions:
  • abs-2 RNAi

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • asb-1 (6239)
  • asb-2 (6239)



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