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Symbol: daf-7 Name: abnormal DAuer Formation Entrez gene ID: 175237 Ensembl gene ID: B0412.2 Species: Worm (Taxid: 6239) Functional description: Encodes a member of the TGF-beta superfamily that affects dauer larvae; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. [UniProt] Observation: daf-7 mutation does not significantly change lifespan [8247153]. Mutations in daf-7 cause up to 50% mean and maximum life-extension. This effect is dependent upon daf-3 and on daf-16 but independent of daf-2. daf-7(e1372) increases mean and maximum lifespan by 13-39% and 55%, respectively. daf-7(m62) increases mean and maximum lifespan by 20-29% and 29% [17900898]. RNAi against daf-7 only in the adulthood increases mean and maximum lifespan by 26 and 7%, respectively [17900898]. Interventions: Assays: Organismal Lifespan Mean: +13 to +39 Maximum: +7 to +55 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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