pex13

Symbol: pex13
Name: peroxin 13
Alias: CG4663;Dmel\CG4663
Entrez gene ID: 36462
Ensembl gene ID: FBgn0033812
Species: Fly (Taxid: 7227)

Functional description:
peroxin 13; peroxin 13 [Source:FlyBase gene name;Acc:FBgn0033812] [Ensembl]; The gene Peroxin 13 is referred to in FlyBase by the symbol Dmel\Pex13 (CG4663, FBgn0033812). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: peroxisome organization; spermatocyte division. 5 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; testis. It has one annotated transcript and one annotated polypeptide. Protein features are: Peroxin 13, N-terminal; Src homology-3 domain; Variant SH3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [FlyBase]

Observation:

Mutation of pex13(KG04339), located in its promoter region, results in lower gene expression and increased lifespan by around 16% and 13% in males and females. pex13 mutation increases mean and maximum lifespan by 23-27/14-19% and 11%, respectively [22509016].



Interventions:
  • pex13 Mutation +14-27% +11%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • References:
  • 22509016: Midlife gene expressions identify modulators of aging through dietary interventions.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PEX13 (9606)
  • PEX13 (9598)
  • PEX13 (9615)
  • PEX13 (9913)
  • Pex13 (10090)
  • Pex13 (10116)
  • PEX13 (9031)
  • pex13 (7955)
  • CG4663 (7227)
  • AgaP_AGAP010074 (7165)
  • prx-13 (6239)
  • PEX13 (4932)
  • KLLA0E19735g (28985)
  • AGOS_ACR230C (33169)
  • GeneID:2674186 (148305)
  • NCU02618 (5141)

  • Inparanoids
  • FBpp0086874 (7227)
  • ENSMUSP00000020523 (10090)
  • ENSRNOP00000007854 (10116)
  • ENSMMUP00000007509 (9544)
  • ENSP00000295030 (9606)
  • YLR191W (4932)



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