Denigma

T08A11.2

Symbol: T08A11.2
Name: Nuclear Hormone Receptor family
Alias: hypothetical protein;WBGENE00011605
Entrez gene ID: 175549
Ensembl gene ID: T08A11.2
Species: Worm (Taxid: 6239)

Functional description:
Protein T08A11.2; T08A11.2 encodes the C. elegans ortholog of splicing factor 3b subunit 1, also known as SAP155; by homology, the product of T08A11.2 is predicted to be a component of the U2 snRNP that is required for pre-mRNA splicing; large-scale RNAi assays indicate that T08A11.2 activity is essential for a number of processes including embryonic development, normal adult lifespan, vulval morphogenesis, locomotion, and transgene expression and localization. [WormBase]

Observation:

T08A11.2 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • T08A11.2 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • SF3B1 (9606)
  • SF3B1 (9598)
  • SF3B1 (9615)
  • SF3B1 (9913)
  • Sf3b1 (10090)
  • Sf3b1 (10116)
  • SF3B1 (9031)
  • sf3b1 (7955)
  • CG2807 (7227)
  • AgaP_AGAP000178 (7165)
  • T08A11.2 (6239)
  • prp10 (4896)
  • GeneID:2674968 (148305)
  • NCU03042 (5141)
  • AT5G64270 (3702)
  • Os02g0147300 (4530)



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