Symbol: sos-1 Name: Drosophila SOS homolog Alias: Drosophila SOS homolog family member (sos-1);WBGENE00004947 Entrez gene ID: 178846 Ensembl gene ID: T28F12.3 Species: Worm (Taxid: 6239) Functional description: Protein SOS-1; Drosophila SOS homolog family member (sos-1) [Source:RefSeq peptide;Acc:NP_504235] [Ensembl]; sos-1 encodes an ortholog of Son of sevenless, a guanine nucleotide exchange factor; sos-1 is required for viability, sex myoblast migration, vulval induction, and oogenesis; sos-1 acts genetically downstream of let-23 and upstream of let-60 with respect to vulval development; SOS-1 binds bovine calmodulin in vitro in a calcium-dependent manner. SOS-1 protein is a Ras-binding guanine nucleotide exchange factor (RasGEF) with one Dbl homology domain (DH) followed by one pleckstrin homology (PH) domain at the N-terminus, and a C-terminal CDC-25 catalytic domain followed by two PxxP motifs. SOS-1 participates in multiple Ras-dependent signaling events. let-341(s1031) mutants display 100% embryonic or early larval lethality; let-341 mutations interact genetically with let-60, gap-1, sem-5, sli-1, and clr-1. Vulval development in a let-341 null mutant suggests that an SOS-1-independent pathway helps activate RAS signaling, and that this hypothetical pathway is unaffected by either SLI-1/Cbl or by PTP-2/SHP. Given that another seven C. elegans genes besides sos-1 (plc-1, pxf-2, F25B3.3, F28B4.2, R05G6.10, T14G10.2, and Y34B4A.4) are currently predicted to encode RasGEF function, there are many possible candidates for a postulated activity parallel to that of SOS-1 in RAS signalling. [WormBase] Observation: sos-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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