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Symbol: ptr-4 Name: PaTched Related family Alias: PaTched Related family member (ptr-4);WBGENE00004219 Entrez gene ID: 180876 Ensembl gene ID: C45B2.7 Species: Worm (Taxid: 6239) Functional description: Protein PTR-4; PaTched Related family member (ptr-4) [Source:RefSeq peptide;Acc:NP_509013] [Ensembl]; ptr-4 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-4 is strongly required for normal molting from L4 to adult stages male tail development (a role conserved in C. briggsae); PTR-4 is also required for normal endocytosis of yolk by oocytes, adult alae formation, growth to full size, locomotion, and viability. [WormBase] Observation: ptr-4 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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