Denigma

irs-1

Symbol: irs-1
Name: Isoleucyl tRNA Synthetase
Alias: Isoleucyl tRNA Synthetase family member (irs-1);WBGENE00002152
Entrez gene ID: 177926
Ensembl gene ID: R11A8.6
Species: Worm (Taxid: 6239)

Functional description:
Isoleucyl tRNA Synthetase; Protein IARS-1; Serine/threonine-protein kinase sax-1 [Source:UniProtKB/Swiss-Prot;Acc:Q2L6W9] [Ensembl]; irs-1 encodes a predicted cytoplasmic isoleucyl-tRNA synthetase (IleRS), an aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-1 activity via RNA-mediated interference (RNAi) results in sterility, embryonic lethality, and slower rates of growth, indicating that IRS-1 is essential for development. [WormBase]

Observation:

irs-1 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • irs-1 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • IARS (9606)
  • IARS (9598)
  • IARS (9615)
  • IARS (9913)
  • Iars (10090)
  • Iars (10116)
  • IARS (9031)
  • iars (7955)
  • Aats-ile (7227)
  • AgaP_AGAP002101 (7165)
  • irs-1 (6239)
  • irs1 (4896)
  • ILS1 (4932)
  • KLLA0E20549g (28985)
  • AGOS_AER394W (33169)
  • GeneID:2676419 (148305)
  • NCU03575 (5141)
  • AT4G10320 (3702)
  • Os06g0645400 (4530)
  • PF13_0179 (5833)



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