daf-19

Symbol: daf-19
Name: Abnormal DAuer Formation
Entrez gene ID: 174577
Ensembl gene ID: F33H1.1
Species: Worm (Taxid: 6239)

Functional description:
May be a transcription factor that regulates some genes of ciliated sensory neurons. May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression. [UniProt]

Observation:

Loss-of-function mutations in daf-19 increase lifespan up to 50% [10617200]. daf-19 mutants are dauer constitutive, dye-filling defective, and lack sensory cilia [7219552; 9475731].



Interventions:
  • daf-19 mutation +50%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RFX2 (9606)
  • RFX2 (9598)
  • RFX2 (9615)
  • RFX2 (9913)
  • Rfx2 (10090)
  • Rfx2 (10116)
  • RFX2 (9031)
  • rfx2 (7955)
  • daf-19 (6239)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit