|
Symbol: dpy-22 Name: DumPY : shorter than wild-type Alias: DumPY : shorter than wild-type family member (dpy-22);WBGENE00001081 Entrez gene ID: 181194 Ensembl gene ID: F47A4.2 Species: Worm (Taxid: 6239) Functional description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of let-60 during vulval induction. Required for asymmetric division of T-cells and for hypodermal development. [UniProt] Observation: dpy-22 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit