Symbol: aph-2 Name: Anterior PHarynx defective Alias: Anterior PHarynx defective family member (aph-2);WBGENE00000148 Entrez gene ID: 172905 Ensembl gene ID: ZC434.6 Species: Worm (Taxid: 6239) Functional description: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProt] Observation: aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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