Denigma: Factor

chn-1

Symbol: chn-1
Name: C-term of Hsp70-iNteracting protein (CHIP family) 1
Alias: C-term of Hsp70-iNteracting protein (CHIP family) family member (chn-1);WBGENE00000500
Entrez gene ID: 172303
Ensembl gene ID: T09B4.10
Species: Worm (Taxid: 6239)

Functional description:
Protein CHN-1; C-term of Hsp70-iNteracting protein (CHIP family) family member (chn-1) [Source:RefSeq peptide;Acc:NP_491781] [Ensembl]; chn-1 encodes an ortholog of mammalian carboxyl-terminus of Hsc70 interacting protein (CHIP), an E4 ubiquitin-chain elongation factor; chn-1 is ubiquitously expressed; chn-1(by155) mutants are viable and superficially normal, but have reduced fertility and arrest as larvae if subjected to heat shock; chn-1 overexpression causes either embryonic lethality (if strong) or defective egg-laying and locomotion, along with constitutive dauer formation (if weak); chn-1(by155) mutations suppress viable unc-45(e286ts) and unc-45(m94ts) mutations, but not lethal unc-45(st604) ones; chn-1(by155) mutants, unlike wild-type, show defective sarcomeres if overexpressing unc-45 from a extrachromosomal array; CHN-1 binds the ubiquitin conjugating enzyme UFD-2, which in turn binds the Hsp90 cochaperone UNC-45; UNC-45 is a substrate for CHN-1- and UFD-2-dependent multiubiquitination; the parkin ortholog PDR-1 binds CHN-1, and requires CHN-1 for self-ubiquitination; chn-1(RNAi) animals accumulate abnormally phosphorylated tau proteins. [WormBase]

Observation:

chn-1 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747].

Interventions:

chn-1 RNAi +7.1% +8.7%

Assays: Organismal Lifespan
Mean: +7.1
Maximum: +8.7

Classification:

Gerontogene

Positive Gerontogene

References:

23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Aging Relevance Analysis/Source:

GenAge