Denigma

rpb-8

Symbol: rpb-8
Name: RNA Polymerase II (B) subunit 8
Alias: RNA Polymerase II (B) subunit family member (rpb-8);WBGENE00017830
Entrez gene ID: 175660
Ensembl gene ID: F26F4.11
Species: Worm (Taxid: 6239)

Functional description:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). [UniProt]

Observation:

rpb-8 RNAi in the adulthood extends the mean lifespan by 6% without any apparent effect on maximum lifespan [23144747].



Interventions:
  • rpb-8 RNAi +6.4% 0%

    • Assays: Organismal Lifespan
    Mean: +6.4
    Maximum: 0

    Classification:
  • Gerontogene
  • Positive Gerontogene


    • References:
  • 23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • POLR2H (9606)
  • POLR2H (9598)
  • POLR2H (9615)
  • POLR2H (9913)
  • Polr2h (10090)
  • Polr2hl (10116)
  • Polr2h (10116)
  • POLR2H (9031)
  • zgc:110289 (7955)
  • LOC792188 (7955)
  • Rpb8 (7227)
  • AgaP_AGAP012397 (7165)
  • rpb-8 (6239)
  • RPB8 (4932)
  • KLLA0D07139g (28985)
  • AGOS_ACR111C (33169)
  • GeneID:2682965 (148305)
  • NCU08030 (5141)
  • NRPB8A (3702)
  • NRPB8B (3702)
  • Os03g0845700 (4530)



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