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Symbol: gsk-3 Name: Glycogen Synthase Kinase family Alias: sgg-1 Entrez gene ID: 173149 Species: Worm (Taxid: 6239) Functional description: Phosphorylates oma-1, a regulator of the oocyte-to- embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension. [UniProt] Observation: gsk-3 RNAi in the adulthood extends the lifespan [New longevity regulators] Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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