Symbol: daf-1 Name: abnormal DAuer Formation Entrez gene ID: 176829 Ensembl gene ID: F29C4.1 Species: Worm (Taxid: 6239) Functional description: Encodes a TGF-beta type I receptor homolog; Controls the dauer/nondauer developmental decision in a range of environmental conditions. [UniProt] Observation: daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Note: Mutation in adults increased mean lifespan by up to 46% and maximum lifespan by 50%. Edit \ Update (Admin) | Delete |
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