daf-1

Symbol: daf-1
Name: abnormal DAuer Formation
Entrez gene ID: 176829
Ensembl gene ID: F29C4.1
Species: Worm (Taxid: 6239)

Functional description:
Encodes a TGF-beta type I receptor homolog; Controls the dauer/nondauer developmental decision in a range of environmental conditions. [UniProt]

Observation:

daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085].



Interventions:
  • daf-1 mutation +18 to +46% +29%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • No Age Effect


  • References:
  • 17900898: The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ACVR1C (9606)
  • ACVR1C (9598)
  • ACVR1C (9615)
  • ACVR1C (9913)
  • Acvr1c (10090)
  • Acvr1c (10116)
  • ACVR1C (9031)
  • daf-1 (6239)

  • Note: Mutation in adults increased mean lifespan by up to 46% and maximum lifespan by 50%.

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