Denigma

gars-1

Symbol: gars-1
Name: T10F2.1
Alias: grs-1;WBGene00001744
Entrez gene ID: 175703
Ensembl gene ID: T10F2.1
Species: Worm (Taxid: 6239)

Functional description:
grs-1 encodes a member of the glycyl-tRNA synthetase family that affects embryonic viability and spindle maintenance during anaphase.; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs (By similarity). [UniProt]

Observation:

grs-1 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • grs-1 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • GARS (9606)
  • GARS (9598)
  • GARS (9615)
  • GARS (9913)
  • Gars (10090)
  • Gars (10116)
  • GARS (9031)
  • si:dkey-276i5.1 (7955)
  • Aats-gly (7227)
  • AgaP_AGAP008604 (7165)
  • grs-1 (6239)
  • grs1 (4896)
  • GRS1 (4932)
  • KLLA0B08932g (28985)
  • AGOS_ADL373W (33169)
  • GeneID:2684476 (148305)
  • NCU00405 (5141)
  • AT1G29880 (3702)
  • Os08g0538000 (4530)
  • PF14_0198 (5833)



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