rab-5

Symbol: rab-5
Name: RAB family 5
Entrez gene ID: 172755
Ensembl gene ID: F26H9.6
Species: Worm (Taxid: 6239)

Functional description:
Protein RAB-5; RAB family member (rab-5) [Source:RefSeq peptide;Acc:NP_492481] [Ensembl]; rab-5 encodes the C. elegans Rab5 GTPase ortholog; RAB-5 activity is required for receptor-mediated yolk endocytosis and for phagosome maturation involved in apoptotic cell clearance; rab-5 mutations also affect localization of P granules and PAR-2, as well as the cytoplasmic appearance of cells in the early embryo and larval development; RAB-5 localizes to early endosomes and maturing phagosomes. [WormBase]

Observation:

rab-5 RNAi in the adulthood reduces mean and maximum lifespan by 38 and 50% [23144747].



Interventions:
  • rab-5 RNAi -38.0%

  • Assays: Organismal Lifespan
    Mean: -38.0
    Maximum: -50.0

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RAB5A (9606)
  • RAB5A (9598)
  • RAB5A (9615)
  • RAB5A (9913)
  • Rab5a (10090)
  • Rab5a (10116)
  • RAB5A (9031)
  • rab5aa (7955)
  • rab5ab (7955)
  • Rab5 (7227)
  • AgaP_AGAP007901 (7165)
  • rab-5 (6239)
  • VPS21 (4932)
  • KLLA0C13728g (28985)
  • AGOS_ACL084C (33169)
  • GeneID:2684396 (148305)
  • NCU06410 (5141)
  • RHA1 (3702)
  • ARA7 (3702)
  • Os12g0631100 (4530)
  • Os03g0666500 (4530)
  • Rab5c (5833)



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