Denigma

rpn-11

Symbol: rpn-11
Name: proteasome Regulatory Particle, Non-ATPase-like 11
Alias: WBGene00004467
Entrez gene ID: 173744
Ensembl gene ID: K07D4.3
Species: Worm (Taxid: 6239)

Functional description:
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). [UniProt]

Observation:

rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747].



Interventions:
  • rpn-11 RNAi -19.3% -25.0%

    • Assays: Organismal Lifespan
    Mean: -19.3
    Maximum: -25.0

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • References:
  • 23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • PSMD14 (9606)
  • PSMD14 (9598)
  • PSMD14 (9615)
  • PSMD14 (9913)
  • Psmd14 (10090)
  • Psmd14 (10116)
  • PSMD14 (9031)
  • psmd14 (7955)
  • Rpn11 (7227)
  • AgaP_AGAP008617 (7165)
  • rpn-11 (6239)
  • rpn11 (4896)
  • RPN11 (4932)
  • KLLA0E14147g (28985)
  • AGOS_AGR006W (33169)
  • GeneID:2684117 (148305)
  • NCU00823 (5141)
  • AT5G23540 (3702)
  • Os05g0371200 (4530)
  • Os01g0267200 (4530)
  • MAL13P1.343 (5833)



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