cdtl-7

Symbol: cdtl-7
Name: CDc-Two Like 7
Entrez gene ID: 175559
Ensembl gene ID: B0285.1
Species: Worm (Taxid: 6239)

Functional description:
Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation (By similarity). [UniProt]

Observation:

RNAi against cdtl-7 starting in the adulthood decreases mean and maximum lifespan by 22 and 25%, respectively [23144747].



Interventions:
  • cdtl-7 RNAi -22.2% -25.0%

  • Assays: Organismal Lifespan
    Mean: -22.2
    Maximum: -25.0

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CDK12 (9606)
  • CDK12 (9615)
  • CDK12 (9913)
  • Cdk12 (10090)
  • Crkrs (10116)
  • CDK12 (9031)
  • CG7597 (7227)
  • AgaP_AGAP004780 (7165)
  • B0285.1 (6239)
  • CDKC;1 (3702)
  • CDKC2 (3702)
  • Os05g0389700 (4530)
  • Os01g0958000 (4530)



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