|
Symbol: MSN2 Name: Multicopy suppressor of SNF1 mutation 2 Entrez gene ID: 855053 Ensembl gene ID: YMR037C Species: Yeast (Taxid: 4932) Functional description: Msn2p; Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression [Source:SGD;Acc:S000004640] [Ensembl] Observation: Deletion of MSN2 and MSN4 extends replicative lifespan and is further extended by cyr1::mTn [14741356]. Deletion of MSN2 and MSN4 does not significantly decrease chronological lifespan under AL, but attenuates chronological lifespan extension by water starvation and 0.5% glucose restriction [18225956] as well as cancels out lifespan extension of cyr1::mTn [14741356] and decreases chronological lifespan extension of ras2 deletion mutant [12586694]. Simultaneous deletion of MSN2 and MSN4 has no effect on chronological lifespan, but prevents lifespan extension by RAS2 deletion [12586694]. msn2 msn4 has no effect on replicative lifespan in PSY316, and does not prevent lifespan extension by DR [11000115] or by high osmolarity [12391171]. Interventions: Assays: Replicative Lifespan Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Note: Should MSN2 and MSN4 deletion mutants be treated as seperate single interventions or double mutants as currently. There is a discripancy regarding their effect on Cyr1 mutant. Edit \ Update (Admin) | Delete |
Comment on This Data Unit