Denigma

SUR4

Symbol: SUR4
Name: SUppressor of Rvs161 and rvs167 mutations 4
Alias: ELO3; SRE1; VBM1; APA1
Entrez gene ID: 851087
Ensembl gene ID: YLR372W
Species: Yeast (Taxid: 4932)

Functional description:
Sur4p; Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis [Source:SGD;Acc:S000004364] [Ensembl]

Observation:

Deletion of SUR4 cancels out replicative lifespan extension of 0.5% glucose DR [18690010].



Interventions:
  • SUR4 deletion

    • Assays: Replicative Lifespan

    Classification:
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • elo-1 (6239)
  • elo-5 (6239)
  • elo-6 (6239)
  • elo-7 (6239)
  • SUR4 (4932)
  • KLLA0B07777g (28985)
  • AGOS_AFR586W (33169)

    • Orthologs
  • LOC712243 (9544)
  • ELOVL4 (9544)
  • CG31523 (7227)
  • ELOVL5 (9606)
  • ELOVL4 (9606)
  • Elovl5 (10116)
  • Elovl6 (10116)
  • elo-3 (6239)
  • CG31141 (7227)
  • Elovl3 (10090)
  • Elo68alpha (7227)
  • Elovl4 (10090)
  • Elovl2 (10116)
  • CG5326 (7227)
  • bond (7227)
  • CG5278 (7227)
  • CG33110 (7227)
  • CG18609 (7227)
  • CG17821 (7227)
  • elo-5 (6239)
  • elo-6 (6239)
  • Elovl6 (10090)
  • Baldspot (7227)
  • Elovl1 (10090)
  • Elovl2 (10090)
  • ELOVL3 (9606)
  • elo-7 (6239)
  • Elovl7 (10090)
  • Elovl5 (10090)
  • ELOVL1 (9606)
  • LOC700557 (9544)
  • elo-4 (6239)
  • Elovl3 (10116)
  • Elovl4 (10116)
  • Elo68beta (7227)
  • CG6660 (7227)
  • ELOVL2 (9544)
  • ELOVL6 (9606)
  • ELOVL3 (9544)
  • eloF (7227)
  • elo-2 (6239)
  • ELOVL7 (9544)
  • Elovl7 (10116)
  • Elovl1 (10116)
  • CG2781 (7227)
  • ELOVL2 (9606)
  • CG30008 (7227)
  • ELOVL6 (9544)
  • CG31522 (7227)
  • ELOVL7 (9606)
  • CG8534 (7227)
  • elo-1 (6239)
  • CG16904 (7227)
  • CG9459 (7227)
  • CG9458 (7227)
  • elo-9 (6239)
  • LOC712243 (9544)
  • ELOVL4 (9544)
  • CG31523 (7227)
  • ELOVL5 (9606)
  • ELOVL4 (9606)
  • Elovl5 (10116)
  • Elovl6 (10116)
  • elo-3 (6239)
  • CG31141 (7227)
  • Elovl3 (10090)
  • Elo68alpha (7227)
  • Elovl4 (10090)
  • Elovl2 (10116)
  • CG5326 (7227)
  • bond (7227)
  • CG5278 (7227)
  • CG33110 (7227)
  • ELO1 (4932)
  • CG18609 (7227)
  • CG17821 (7227)
  • elo-5 (6239)
  • elo-6 (6239)
  • Elovl6 (10090)
  • Baldspot (7227)
  • Elovl1 (10090)
  • Elovl2 (10090)
  • ELOVL3 (9606)
  • elo-7 (6239)
  • Elovl7 (10090)
  • Elovl5 (10090)
  • ELOVL1 (9606)
  • LOC700557 (9544)
  • elo-4 (6239)
  • Elovl3 (10116)
  • Elovl4 (10116)
  • Elo68beta (7227)
  • CG6660 (7227)
  • ELOVL2 (9544)
  • ELOVL6 (9606)
  • FEN1 (4932)
  • ELOVL3 (9544)
  • eloF (7227)
  • elo-2 (6239)
  • ELOVL7 (9544)
  • Elovl7 (10116)
  • Elovl1 (10116)
  • CG2781 (7227)
  • ELOVL2 (9606)
  • CG30008 (7227)
  • ELOVL6 (9544)
  • CG31522 (7227)
  • ELOVL7 (9606)
  • CG8534 (7227)
  • elo-1 (6239)
  • CG16904 (7227)
  • CG9459 (7227)
  • CG9458 (7227)
  • elo-9 (6239)



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