Denigma

FET3

Symbol: FET3
Name: FErrous Transport 3
Entrez gene ID: 855080
Ensembl gene ID: YMR058W
Species: Yeast (Taxid: 4932)

Functional description:
Multicooper oxidase, that along with iron permiase (Ftr1), compromises a high affinity iron uptake system; Fet3p; Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases [Source:SGD;Acc:S000004662] [Ensembl]

Observation:

FET3 mutation slightly shortens chronological lifespan under AL. Its chronological lifespan is not extended by 0.5% glucose or amino-acid DR [20421943]. FET3 is one of several iron related genes that are up-regulated in response to increasing strength of glucose DR [18679056].



Interventions:
  • FET3 deletion

    • Assays: Chronological Lifespan

    Classification:
  • DR-Induced
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • fio1 (4896)
  • FET3 (4932)
  • KLLA0F26400g (28985)
  • GeneID:2681067 (148305)
  • NCU03498 (5141)
  • AT4G39830 (3702)

    • Orthologs
  • CG42345 (7227)
  • CG32557 (7227)
  • F21D5.3 (6239)
  • CG3759 (7227)
  • CG5959 (7227)
  • fio1 (4896)
  • FET5 (4932)
  • CG42345 (7227)
  • CG32557 (7227)
  • F21D5.3 (6239)
  • CG3759 (7227)
  • CG5959 (7227)
  • fio1 (4896)
  • (4932)



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