Denigma

VPS30

Symbol: VPS30
Name: Vacuolar Protein Sorting 30
Alias: APG6; ATG6; VPT30
Entrez gene ID: 855983
Ensembl gene ID: YPL120W
Species: Yeast (Taxid: 4932)

Functional description:
Vps30p; Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1 [Source:SGD;Acc:S000006041] [Ensembl]

Observation:

VPS30 deletion prevents chronological lifespan extension induced by amino-acid DR [20421943].



Interventions:
  • VPS30 deletion

    • Assays: Chronological Lifespan

    Classification:
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • BECN1 (9606)
  • BECN1 (9598)
  • BECN1 (9913)
  • Becn1 (10090)
  • Becn1 (10116)
  • BECN1 (9031)
  • becn1 (7955)
  • Atg6 (7227)
  • AgaP_AGAP003858 (7165)
  • bec-1 (6239)
  • SPAC20G8.10c (4896)
  • VPS30 (4932)
  • KLLA0F01166g (28985)
  • AGOS_ACR154W (33169)
  • GeneID:2676971 (148305)
  • NCU03122 (5141)
  • AT3G61710 (3702)
  • Os03g0644000 (4530)
  • Os01g0681400 (4530)

    • Orthologs
  • SPAC20G8.10c (4896)
  • Becn1 (10090)
  • RGD1563293 (10116)
  • bec-1 (6239)
  • LOC715431 (9544)
  • Atg6 (7227)
  • BECN1 (9606)
  • BECN1 (9544)
  • Becn1 (10116)
  • bec-1 (6239)
  • SPAC20G8.10c (4896)
  • Becn1 (10090)
  • RGD1563293 (10116)
  • bec-1 (6239)
  • LOC715431 (9544)
  • Atg6 (7227)
  • BECN1 (9606)
  • BECN1 (9544)
  • Becn1 (10116)
  • bec-1 (6239)



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